Complex pathways to cooperation emergent from asymmetry in heterogeneous populations.

Cooperation within asymmetric populations has garnered significant attention in evolutionary games. This paper explores cooperation evolution in populations with weak and strong players, using a game model where players choose between cooperation and defection. Asymmetry stems from different benefits for strong and weak cooperators, with their benefit ratio indicating the degree of asymmetry. Varied rankings of parameters including the asymmetry degree, cooperation costs, and benefits brought by weak players give rise to scenarios including the prisoner's dilemma (PDG) for both player types, the snowdrift game (SDG), and mixed PDG-SDG interactions. Our results indicate that in an infinite well-mixed population, defection remains the dominant strategy when strong players engage in the prisoner's dilemma game. However, if strong players play snowdrift games, global cooperation increases with the proportion of strong players. In this scenario, strong cooperators can prevail over strong defectors when the proportion of strong players is low, but the prevalence of cooperation among strong players decreases as their proportion increases. In contrast, within a square lattice, the optimum global cooperation emerges at intermediate proportions of strong players with moderate degrees of asymmetry. Additionally, weak players protect cooperative clusters from exploitation by strong defectors. This study highlights the complex dynamics of cooperation in asymmetric interactions, contributing to the theory of cooperation in asymmetric games.

Study on the Baseline Factors and Platelet Indices That Predict Outcome of Acute Ischemic Stroke Patients after Thrombolytic Therapy.

BACKGROUND: The aim of the study was to investigate the baseline characters that influence 3-month clinical outcomes in patients with acute ischemic stroke (AIS) after thrombolytic therapy. METHODS: We consecutively enrolled 241 AIS patients who are treated with thrombolytic therapy with recombinant tissue plasminogen activator. Baseline characters were measured on admission including the National Institutes of Health Stroke Scale (NIHSS), Trial of Org 10172 in Acute Stroke Treatment (TOAST), risk factors, platelet indices, and lipid parameters. The subjects were divided into good or poor functional outcomes based on modified Rankin Scale at 3 months. The multivariate logistic regression was performed to explore the association between baseline factors and outcomes. Pearson correlation was used to investigate whether linear associations existed between platelet indices in different outcomes. RESULTS: Multivariate logistic regression analysis showed that the NIHSS, TOAST classification, diabetes, mean platelet volume (MPV) are important factors for predicting clinical outcomes after 3 months in AIS patients. We found a correlation between elevated MPV and worse outcome at 3 months, particularly in large-artery atherosclerosis stroke patients. MPV and platelet count are negative correlated (r = -0.375, p = 0.000). MPV and platelet-to-lymphocyte ratio (PLR) (r = 0.83, p = 0.000), MPV and platelet distribution width (PDW) (r = 0.820, p = 0.000) both have highly positive linear correlations in patients with good outcome. CONCLUSIONS: Overall, lower NIHSS and MPV levels on admission were predictors of good functional outcomes in patients with AIS after undergoing thrombolytic therapy. The correlations between MPV, PDW, and PLR may be helpful to evaluate prognosis in stroke patients and deserve further exploration.

Fatal and Rapid Progressive Isolated Cerebral Mucormycosis Involving the Bilateral Basal Ganglia: A Case Report.

Isolated cerebral mucormycosis is a clinical type of mucormycosis that is estimated to account for 8% of all mucormycosis cases. The clinical symptoms of isolated cerebral mucormycosis are elusive, and thus conventional techniques often lake sensitivity and specificity. Moreover, cultures are often negative, even when direct microscopy examination is positive. Although histopathology will probably remain the gold standard for the diagnosis of mucormycosis, obtaining a biopsy specimen is not always feasible in most vulnerable populations. Thus, molecular approaches are currently used as an advantageous assistant examination method to improve the early identification of the causative agent and subsequently guide therapy to improve the prognosis of patients. Here, we report a case of isolated cerebral mucormycosis caused by Rhizopus microspores in a healthy young adult that was identified using next-generation sequencing technology.